Dosimetric Analysis and Effect of Different Definitions of Prescription Point “A” to OAR in High Dose Rate Brachytherapy for Cervical Cancer

Purpose: Dosimetric analysis and effect of different definitions prescription point “A” to OAR in high dose rate brachytherapy for cervical cancer. Methods Materials: This retrospective comparative dosimetric study is based on the data 25 patients with histologically proven carcinoma treated HDR (high-dose-rate) brachytherapy. Patients received 21 Gy three fractions (7.0 X fractions) A (AMAN, revised Manchester definition). Further, were replanned new (AABS) as per American Brachytherapy Society/ICRU 89 which defined CT images. The compiled was then compared observed from (AMAN). Results: When AMAN normalization method used, mean bladder at 0.1cc, 1cc, 2cc 5cc obtained 1121.2±54.5, 1058.7±44.1, 875.0±38.6, 780.5±35.9, 641.2±29.5 cGy respectively. Likewise, using ICRU-89 (ABS) method, 0.1 cc, 0.2 1 2 volumes 1178±156.1,1110.0±130.8, 921.6±111.4, 826.6±101.32, 673.3±80.9 cGy, For rectum, (MAN) plans, cc,1 rectum 680±143.5, 652.53±129.8,574.25±131.1, 530±126.9, 452.5±121.2cGy, plan, 0.2cc, volume 707.5±148.1, 678.7±128.7, 596.2±135.6, 551.25±127.44 471.25±122.64 statistical difference Total Reference Air Kerma rate, V100 (cc), bladder, found significant. Conclusion: present attempts analyze differences dose, well size enclosed prescribed Isodose curve following ICRU 38 ABS-ICRU recommendations about intracavitary cervix cancer With system being more static, i.e., lesser variation geometric changes, it preferable comparison ABS system.